SubtiBank SubtiBank
Version comparison:

2017-12-04 14:14:122025-05-13 19:28:13

description

intramembrane metalloprotease, processing of pro-sigma-K to active SigK

intramembrane metalloprotease (site 2 protease), processing of pro-sigma-K to active [[protein|SigK]]

locus

BSU27970

BSU_27970

geneLength

864

867

function

processing of pro-sigma-K to active SigK

processing of pro-sigma-K to active [[protein|SigK]]

ec

outlinks

bsu

BSU27970

BSU_27970

Gene

Coordinates

2,855,973 → 2,856,839

2,855,973 2,856,839

The protein

Protein family

peptidase M50B family (according to Swiss-Prot)

[SW|peptidase M50B family] (according to UniProt)

The protein

[SW|Domains]

C-terminal cystathionine-beta-synthase (CBS) domain, this domain binds ATP [Pubmed|19805276]

C-terminal [SW|CBS domain], this domain binds ATP [Pubmed|19805276]

The protein

Effectors of protein activity

ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level [Pubmed|19805276]

ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level [Pubmed|19805276]

[[protein|SpoIVFB]] is kept inactive by the interaction with [[protein|SpoIVFA]] and [[protein|BofA]] [pubmed|15087499]

The protein

[SW|Localization]

integral membrane protein [Pubmed|11959848]

mother cell membrane [Pubmed|24243021]

mother cell integral membrane protein [Pubmed|24243021,11959848]

Biological materials

Mutant

BKE27970 (Δ[[gene|spoIVFB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC

BKK27970 (Δ[[gene|spoIVFB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC

BKE27970 ([[gene|spoIVFB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC

BKK27970 ([[gene|spoIVFB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC

References

Reviews

20836086, 23479438, 19189971, 24099006

20836086, 23479438, 19189971, 24099006, 31350897

References

Original Publications

11959848, 9501233, 12940997, 1577688, 12060714, 9078383, 1942049, 10611287, 15383836, 16818230, 19805276, 15699190, 23585539, 23995631, 15087499, 24243021, 22383849, 26953342

The protein

Paralogous protein(s)

[[this]]

References

Original Publication

11959848, 9501233, 12940997, 1577688, 12060714, 9078383, 1942049, 10611287, 15383836, 16818230, 19805276, 15699190, 23585539, 23995631, 15087499, 24243021, 22383849, 26953342, 29180425, 30403663, 32515031