2017-12-04 14:14:122025-05-23 20:21:02
description
intramembrane metalloprotease, processing of pro-sigma-K to active SigK
intramembrane metalloprotease (site 2 protease), processing of pro-sigma-K to active [[protein|SigK]]
locus
BSU27970
BSU_27970
geneLength
864
867
function
processing of pro-sigma-K to active SigK
processing of pro-sigma-K to active [[protein|SigK]]
ec
outlinks
bsu
BSU27970
BSU_27970
Gene
Coordinates
2,855,973 → 2,856,839
2,855,973 2,856,839
The protein
Protein family
peptidase M50B family (according to Swiss-Prot)
[SW|peptidase M50B family] (according to UniProt)
The protein
[SW|Domains]
C-terminal cystathionine-beta-synthase (CBS) domain, this domain binds ATP [Pubmed|19805276]
C-terminal [SW|CBS domain], this domain binds ATP [Pubmed|19805276]
The protein
Effectors of protein activity
ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level [Pubmed|19805276]
ATP regulates substrate access to the active site and renders cleavage sensitive to the cellular energy level [Pubmed|19805276]
[[protein|SpoIVFB]] is kept inactive by the interaction with [[protein|SpoIVFA]] and [[protein|BofA]] [pubmed|15087499]
The protein
[SW|Localization]
integral membrane protein [Pubmed|11959848]
mother cell membrane [Pubmed|24243021]
mother cell integral membrane protein [Pubmed|24243021,11959848]
Biological materials
Mutant
BKE27970 (Δ[[gene|spoIVFB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC
BKK27970 (Δ[[gene|spoIVFB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC
BKE27970 ([[gene|spoIVFB]]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC
BKK27970 ([[gene|spoIVFB]]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK27970 BGSC], [Pubmed|28189581], upstream reverse: _UP1_GATCTTTAAGATAAGGTCGA, downstream forward: _UP4_TAAAACTGATTGACAAACGC
References
Reviews
References
Original Publications
The protein
Paralogous protein(s)
[[this]]
References
Original Publication